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A review and update on melanocyte stimulating hormone therapy: afamelanotide.
[erythropoietic protoporphyria]
Afamelanotide
(
[
Nle
4
-
D-Phe
7
]
-
alpha-
MSH
)
is
an
analog
of
alpha-melanocyte
stimulating
hormone
given
as
a
subcutaneous
injection
.
Afamelanotide
is
currently
undergoing
phase
II
and
III
trials
in
Europe
and
the
US
for
skin
diseases
including
vitiligo
,
erythropoietic
protoporphyria
,
polymorphic
light
eruption
and
prevention
of
actinic
keratoses
in
organ
transplant
recipients
.
Unregulated
analogs
and
chemicals
are
being
sold
online
ahead
of
formal
approval
.
A
number
of
counterfeit
chemicals
,
'
Melanotans
'
are
being
sold
for
tanning
purposes
.
Currently
,
afamelanotide
is
already
on
the
market
in
Italy
and
Switzerland
for
patients
with
erythropoietic
protoporphyria
.
This
paper
will
review
the
current
literature
on
this
promising
compound
.