Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Protective action of antioxidants on hepatic damage induced by griseofulvin.
[erythropoietic protoporphyria]
Erythropoietic
protoporphyria
(
EPP
)
is
a
disease
associated
with
ferrochelatase
deficiency
and
characterized
by
the
accumulation
of
protoporphyrin
IX
(
PROTO
IX
)
in
erythrocytes
,
liver
,
and
skin
.
In
some
cases
,
a
severe
hepatic
failure
and
cholestasis
were
observed
.
Griseofulvin
(
Gris
)
develops
an
experimental
EPP
with
hepatic
manifestations
in
mice
such
as
PROTO
IX
accumulation
followed
by
cellular
damage
as
wells
as
necrotic
and
inflammatory
processes
.
The
antioxidant
defense
system
was
also
altered
.
The
aim
was
to
evaluate
the
possible
protective
effect
of
different
antioxidant
compounds
:
trolox
(
Tx
)
,
ascorbic
acid
(
Asc
)
,
the
combination
Tx
and
Asc
,
melatonin
(
Mel
)
,
and
the
polyphenols
:
ellagic
acid
,
quercetin
,
chlorogenic
acid
,
caffeic
acid
,
gallic
acid
,
and
ferulic
acid
on
liver
damage
and
oxidative
stress
markers
in
a
mouse
model
of
EPP
.
Coadministration
of
Gris
with
Tx
,
Asc
,
and
its
combination
,
or
Mel
mainly
affected
heme
biosynthetic
pathway
,
resulting
in
a
decrease
in
ALA
-S
activity
which
was
increased
by
Gris
,
while
the
tested
polyphenols
exerted
a
protective
effect
on
oxidative
stress
,
decreasing
lipid
peroxidation
and
the
activity
of
some
antioxidant
enzymes
.
In
conclusion
,
antioxidant
compounds
can
only
protect
partially
against
the
liver
damage
induced
by
Gris
,
reducing
oxidative
stress
or
acting
on
heme
regulation
.
Diseases
Validation
Diseases presenting
"liver damage"
symptom
benign recurrent intrahepatic cholestasis
erythropoietic protoporphyria
neonatal adrenoleukodystrophy
scrub typhus
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom