Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
Salvage lenalidomide in four rare oncological diseases.
[erdheim-chester disease]
In
rare
disorders
,
there
are
often
no
standard
therapy
recommendations
.
Patients
with
refractory
disease
may
require
novel
experimental
approaches
.
Applied
as
second
-
up
to
fourth
-line
treatment
,
lenalidomide
(
10
-
25
mg
perorally
on
days
1
-
21
in
a
28
-
day
cycle
)
was
used
in
our
cohort
of
four
adult
patients
with
aggressive
,
multisystem
and
relapsing
diseases
.
Complete
and
long
-lasting
remissions
(
more
than
1
year
,
no
maintenance
therapy
)
were
achieved
in
patients
with
Langerhans
cell
histiocytosis
(
11
cycles
,
combination
with
dexamethasone
and
etoposide
,
consolidated
by
allogeneic
blood
stem
cell
transplant
)
and
plasma-cell
Castleman
disease
(
15
cycles
,
monotherapy
)
.
Mixed
response
with
complete
disappearance
of
brain
infiltrates
was
reached
in
Erdheim-
Chester
disease
(
6
cycles
,
monotherapy
)
and
gastrointestinal
bleeding
was
well
controlled
in
multiple
angiomatosis
(
9
cycles
,
combination
with
thalidomide
)
.
For
disease
activity
evaluation
each
patient
underwent
fluorine-
18
-
fluorodeoxyglucose
positron
emission
tomography
/
computed
tomography
scan
imaging
,
which
was
complemented
by
clinical
and
laboratory
investigations
.
Diseases
Validation
Diseases presenting
"gastrointestinal bleeding"
symptom
benign recurrent intrahepatic cholestasis
coats disease
erdheim-chester disease
liposarcoma
pleomorphic liposarcoma
This symptom has already been validated