Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
The development of cognitive control in children with chromosome 22q11.2 deletion syndrome.
[22q11.2 deletion syndrome]
Chromosome
22
q
11
.
2
Deletion
Syndrome
(
22
q
11
.
2
DS
)
is
caused
by
the
most
common
human
microdeletion
,
and
it
is
associated
with
cognitive
impairments
across
many
domains
.
While
impairments
in
cognitive
control
have
been
described
in
children
with
22
q
11
.
2
DS
,
the
nature
and
development
of
these
impairments
are
not
clear
.
Children
with
22
q
11
.
2
DS
and
typically
developing
children
(
TD
)
were
tested
on
four
well-validated
tasks
aimed
at
measuring
specific
foundational
components
of
cognitive
control
:
response
inhibition
,
cognitive
flexibility
,
and
working
memory
.
Molecular
assays
were
also
conducted
in
order
to
examine
genotype
of
catechol-
O-
methyltransferase
(
COMT
)
,
a
gene
located
within
the
deleted
region
in
22
q
11
.
2
DS
and
hypothesized
to
play
a
role
in
cognitive
control
.
Mixed
model
regression
analyses
were
used
to
examine
group
differences
,
as
well
as
age-related
effects
on
cognitive
control
component
processes
in
a
cross-sectional
analysis
.
Regression
models
with
COMT
genotype
were
also
conducted
in
order
to
examine
potential
effects
of
the
different
variants
of
the
gene
.
Response
inhibition
,
cognitive
flexibility
,
and
working
memory
were
impaired
in
children
with
22
q
11
.
2
DS
relative
to
TD
children
,
even
after
accounting
for
global
intellectual
functioning
(
as
measured
by
full-scale
IQ
)
.
When
compared
with
TD
individuals
,
children
with
22
q
11
.
2
DS
demonstrated
atypical
age-related
patterns
of
response
inhibition
and
cognitive
flexibility
.
Both
groups
demonstrated
typical
age-related
associations
with
working
memory
.
The
results
of
this
cross-sectional
analysis
suggest
a
specific
aberration
in
the
development
of
systems
mediating
response
inhibition
in
a
sub-set
of
children
with
22
q
11
.
2
DS
.
It
will
be
important
to
follow
up
with
longitudinal
analyses
to
directly
examine
these
developmental
trajectories
,
and
correlate
neurocognitive
variables
with
clinical
and
adaptive
outcome
measures
.
Diseases
Validation
Diseases presenting
"and working memory were impaired in children with 22q11"
symptom
22q11.2 deletion syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom
