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Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.
[epidermolysis bullosa simplex]
Keratin
1
(
KRT
1
)
and
its
heterodimer
partner
keratin
10
(
KRT
10
)
are
major
constituents
of
the
intermediate
filament
cytoskeleton
in
suprabasal
epidermis
.
KRT
1
mutations
cause
epidermolytic
ichthyosis
in
humans
,
characterized
by
loss
of
barrier
integrity
and
recurrent
erythema
.
In
search
of
the
largely
unknown
pathomechanisms
and
the
role
of
keratins
in
barrier
formation
and
inflammation
control
,
we
show
here
that
Krt
1
is
crucial
for
maintenance
of
skin
integrity
and
participates
in
an
inflammatory
network
in
murine
keratinocytes
.
Absence
of
Krt
1
caused
a
prenatal
increase
in
interleukin-
18
(
IL
-
18
)
and
the
S
100
A
8
and
S
100
A
9
proteins
,
accompanied
by
a
barrier
defect
and
perinatal
lethality
.
Depletion
of
IL
-
18
partially
rescued
Krt
1
(
-
/
-
)
mice
.
IL
-
18
release
was
keratinocyte-autonomous
,
KRT
1
and
caspase-
1
dependent
,
supporting
an
upstream
role
of
KRT
1
in
the
pathology
.
Finally
,
transcriptome
profiling
revealed
a
Krt
1
-
mediated
gene
expression
signature
similar
to
atopic
eczema
and
psoriasis
,
but
different
from
Krt
5
deficiency
and
epidermolysis
bullosa
simplex
.
Our
data
suggest
a
functional
link
between
KRT
1
and
human
inflammatory
skin
diseases
.
Diseases
Validation
Diseases presenting
"human inflammatory skin diseases"
symptom
epidermolysis bullosa simplex
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