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Topical diacerein for epidermolysis bullosa: a randomized controlled pilot study.
[epidermolysis bullosa simplex]
Blistering
in
epidermolysis
bullosa
simplex
type
Dowling-
Meara
(
EBS
-
DM
)
is
associated
with
an
inflammatory
phenotype
,
which
can
be
disrupted
by
diacerein
in
vitro
.
In
this
pilot
study
we
hypothesized
,
that
a
topical
formulation
of
diacerein
1
%
reduces
blistering
.
Five
patients
initially
applied
diacerein
underneath
both
armpits
.
Then
,
each
participant
received
1
%
diacerein-cream
for
one
armpit
,
and
placebo
for
the
other
(
randomized
withdrawal
)
.
The
number
of
blisters
was
reduced
significantly
(
left
:
-
78
%
;
right
:
-
66
%
of
baseline
)
within
two
weeks
and
remained
significantly
below
the
initial
level
even
during
withdrawal
in
four
patients
.
These
findings
point
to
a
relevant
effect
of
diacerein
and
provide
important
information
for
a
confirmative
study
.