Deviant dynamics of EEG resting state pattern in 22q11.2 deletion syndrome adolescents: A vulnerability marker of schizophrenia?

[22q11.2 deletion syndrome]

Previous studies have repeatedly found altered temporal characteristics of EEG microstates in schizophrenia . The aim of the present study was to investigate whether adolescents affected by the 22 q 11 .2 deletion syndrome (22 q 11 DS ), known to have a 30 fold increased risk to develop schizophrenia , already show deviant EEG microstates . If this is the case , temporal alterations of EEG microstates in 22 q 11 DS individuals could be considered as potential biomarkers for schizophrenia . We used high -density (204 channel ) EEG to explore between-group microstate differences in 30 adolescents with 22 q 11 DS and 28 age-matched controls . We found an increased presence of one microstate class (class C ) in the 22 q 11 DS adolescents with respect to controls that was associated with positive prodromal symptoms (hallucinations ). A previous across-age study showed that the class C microstate was more present during adolescence and a combined EEG-fMRI study associated the class C microstate with the salience resting state network , a network known to be dysfunctional in schizophrenia . Therefore , the increased class C microstates could be indexing the increased risk of 22 q 11 DS individuals to develop schizophrenia if confirmed by our ongoing longitudinal study comparing both the adult 22 q 11 DS individuals with and without schizophrenia , as well as schizophrenic individuals with and without 22 q 11 DS .

Diseases
Validation

Diseases presenting "previous across-age study" symptom

22q11.2 deletion syndrome

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