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Collagen VII plays a dual role in wound healing.
[dystrophic epidermolysis bullosa]
Although
a
host
of
intracellular
signals
is
known
to
contribute
to
wound
healing
,
the
role
of
the
cell
microenvironment
in
tissue
repair
remains
elusive
.
Here
we
employed
2
different
mouse
models
of
genetic
skin
fragility
to
assess
the
role
of
the
basement
membrane
protein
collagen
VII
(
COL
7
A
1
)
in
wound
healing
.
COL
7
A
1
secures
the
attachment
of
the
epidermis
to
the
dermis
,
and
its
mutations
cause
a
human
skin
fragility
disorder
coined
recessive
dystrophic
epidermolysis
bullosa
(
RDEB
)
that
is
associated
with
a
constant
wound
burden
.
We
show
that
COL
7
A
1
is
instrumental
for
skin
wound
closure
by
2
interconnected
mechanisms
.
First
,
COL
7
A
1
was
required
for
re
-epithelialization
through
organization
of
laminin-
332
at
the
dermal-epidermal
junction
.
Its
loss
perturbs
laminin-
332
organization
during
wound
healing
,
which
in
turn
abrogates
strictly
polarized
expression
of
integrin
α
6
β
4
in
basal
keratinocytes
and
negatively
impacts
the
laminin-
332
/
integrin
α
6
β
4
signaling
axis
guiding
keratinocyte
migration
.
Second
,
COL
7
A
1
supported
dermal
fibroblast
migration
and
regulates
their
cytokine
production
in
the
granulation
tissue
.
These
findings
,
which
were
validated
in
human
wounds
,
identify
COL
7
A
1
as
a
critical
player
in
physiological
wound
healing
in
humans
and
mice
and
may
facilitate
development
of
therapeutic
strategies
not
only
for
RDEB
,
but
also
for
other
chronic
wounds
.
Diseases
Validation
Diseases presenting
"skin fragility"
symptom
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erythropoietic protoporphyria
harlequin ichthyosis
junctional epidermolysis bullosa
kindler syndrome
This symptom has already been validated
