Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
Generation of 3D skin equivalents fully reconstituted from human induced pluripotent stem cells (iPSCs).
[dystrophic epidermolysis bullosa]
Recent
generation
of
patient-
specific
induced
pluripotent
stem
cells
(
PS-iPSCs
)
provides
significant
advantages
for
cell-
and
gene
-based
therapy
.
Establishment
of
iPSC-based
therapy
for
skin
diseases
requires
efficient
methodology
for
differentiating
iPSCs
into
both
keratinocytes
and
fibroblasts
,
the
major
cellular
components
of
the
skin
,
as
well
as
the
reconstruction
of
skin
structures
using
these
iPSC-derived
skin
components
.
We
previously
reported
generation
of
keratinocytes
from
human
iPSCs
for
use
in
the
treatment
of
recessive
dystrophic
epidermolysis
bullosa
(
RDEB
)
caused
by
mutations
in
the
COL
7
A
1
gene
.
Here
,
we
developed
a
protocol
for
differentiating
iPSCs
into
dermal
fibroblasts
,
which
also
produce
type
VII
collagen
and
therefore
also
have
the
potential
to
treat
RDEB
.
Moreover
,
we
generated
in
vitro
3
D
skin
equivalents
composed
exclusively
human
iPSC-derived
keratinocytes
and
fibroblasts
for
disease
models
and
regenerative
therapies
for
skin
diseases
,
first
demonstrating
that
iPSCs
can
provide
the
basis
for
modeling
a
human
organ
derived
entirely
from
two
different
types
of
iPSC-derived
cells
.
Diseases
Validation
Diseases presenting
"skin diseases"
symptom
cutaneous mastocytosis
dentinogenesis imperfecta
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erythropoietic protoporphyria
fabry disease
harlequin ichthyosis
inclusion body myositis
junctional epidermolysis bullosa
kindler syndrome
lamellar ichthyosis
oculocutaneous albinism
papillon-lefèvre syndrome
sneddon syndrome
systemic capillary leak syndrome
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