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Evaluation of wound care options in patients with recessive dystrophic epidermolysis bullosa: a costly necessity.
[dystrophic epidermolysis bullosa]
Recessive
dystrophic
epidermolysis
bullosa
(
RDEB
)
is
a
genetic
disorder
in
which
mutations
in
collagen
VII
,
the
main
component
of
the
anchoring
fibril
,
lead
to
skin
fragility
and
to
the
development
of
acute
and
chronic
wounds
.
Wound
care
and
dressing
changes
are
an
important
part
of
the
daily
lives
of
individuals
with
RDEB
.
Ideal
wound
care
should
improve
wound
healing
,
minimize
pain
,
and
improve
quality
of
life
.
The
objective
of
the
current
study
was
to
review
wound
care
options
that
might
be
used
in
a
patient
with
RDEB
and
calculate
the
cost
of
these
various
options
based
on
publicly
available
pricing
of
wound
care
products
.
There
is
a
wide
range
of
costs
for
wound
care
options
in
patients
with
RDEB
.
For
example
,
a
1
-
day
supply
of
dressing
for
a
neonate
boy
with
RDEB
ranges
from
$
10
.
64
for
the
least
expensive
option
to
$
127
.
54
for
the
most
expensive
option
.
Wound
care
in
patients
with
severe
,
generalized
RDEB
has
not
only
a
significant
economic
effect
,
but
also
directly
affects
quality
of
life
in
this
patient
population
.
Although
randomized
controlled
trials
evaluating
different
wound
care
products
in
patients
with
RDEB
are
lacking
,
small
studies
and
expert
opinion
support
the
use
of
specialized
nonadherent
dressings
that
minimize
skin
trauma
and
promote
wound
healing
.
Until
there
is
a
cure
,
prospective
studies
are
needed
to
assess
pain
,
quality
of
life
,
and
wound
healing
associated
with
the
use
of
specialized
wound
care
products
for
this
life-altering
condition
.
Diseases
Validation
Diseases presenting
"small studies"
symptom
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
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