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MMP13 can be a useful differentiating marker between squamous cell carcinoma and benign hyperkeratotic lesions in recessive dystrophic epidermolysis bullosa.
[dystrophic epidermolysis bullosa]
Recessive
dystrophic
epidermolysis
bullosa
(
RDEB
)
is
a
severe
hereditary
mechanobullous
disease
resulting
from
mutations
in
the
COL
7
A
1
,
gene
coding
for
type
VII
collagen
.
RDEB
patients
tend
to
develop
squamous
cell
carcinomas
(
SCC
)
at
sites
of
chronic
ulceration
or
scarring
on
the
whole
body
.
Distinguishing
SCC
from
benign
hyperkeratotic
lesions
is
often
difficult
not
only
clinically
but
also
histologically
in
RDEB
patients
.
We
investigated
several
matrix
metalloendopeptidase
(
MMP
)
subtypes
by
comparing
the
DNA
amplification
microarray
findings
between
evident
SCC
and
benign
hyperkeratotic
lesion
in
the
same
RDEB
patient
.
We
report
that
MMP
13
was
found
to
be
strongly
positive
in
SCC
but
negative
in
benign
hyperkeratotic
lesions
.
We
found
that
there
is
an
evident
difference
in
the
transitional
area
between
SCC
and
benign
hyperkeratotic
lesions
.
We
propose
that
MMP
13
may
be
a
useful
differentiating
marker
between
squamous
cell
carcinoma
and
benign
hyperkeratotic
lesions
in
RDEB
.
This
article
is
protected
by
copyright
.
All
rights
reserved
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated