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A random Abstract
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Role of genes in oro-dental diseases.
[dentinogenesis imperfecta]
In
oral
cavity
,
the
spectrum
of
diseases
due
to
genetic
alterations
ranges
from
developmental
disturbances
of
teeth
to
the
pre-cancerous
and
cancerous
lesions
.
Of
late
,
significant
progress
has
been
made
in
the
molecular
analysis
of
tumors
.
With
molecular
genetic
testing
emerging
as
diagnostic
,
prognostic
,
and
therapeutic
approach
,
a
review
of
genetic
alterations
ranging
from
the
development
of
oro-
facial
structures
to
the
tumors
in
the
head
and
neck
region
are
addressed
in
this
article
.
The
functional
regulatory
aspect
of
genes
in
relation
to
oro-
facial
structures
are
discussed
separately
,
i
.
e
.
,
in
relation
to
tooth
genesis
,
tooth
agenesis
(
non-syndromic
,
syndromic
)
,
tooth
structural
alterations
,
syndromic
oro-
facial
defects
,
bone
diseases
,
skin
diseases
(
genodermatoses
)
,
and
malignant
tumors
.
In
this
literature
,
various
genes
involved
in
the
development
of
the
oro-
facial
structures
and
tooth
in
particular
are
discussed
.
The
genetic
basis
of
disorders
in
the
tooth
development
(
agenesis
,
hypodontia
)
,
tooth
structural
defects
like
amelogenesis
imperfecta
(
AI
)
,
dentinogenesis
imperfecta
(
DI
)
,
and
oro-
facial
structural
alterations
(
various
syndromes
)
are
explained
.
Diseases
Validation
Diseases presenting
"hypodontia"
symptom
dentin dysplasia
dentinogenesis imperfecta
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
kabuki syndrome
oligodontia
This symptom has already been validated
