Role of genes in oro-dental diseases.

[dentinogenesis imperfecta]

In oral cavity , the spectrum of diseases due to genetic alterations ranges from developmental disturbances of teeth to the pre-cancerous and cancerous lesions . Of late , significant progress has been made in the molecular analysis of tumors . With molecular genetic testing emerging as diagnostic , prognostic , and therapeutic approach , a review of genetic alterations ranging from the development of oro-facial structures to the tumors in the head and neck region are addressed in this article . The functional regulatory aspect of genes in relation to oro-facial structures are discussed separately , i .e ., in relation to tooth genesis , tooth agenesis (non-syndromic , syndromic ), tooth structural alterations , syndromic oro-facial defects , bone diseases , skin diseases (genodermatoses ), and malignant tumors . In this literature , various genes involved in the development of the oro-facial structures and tooth in particular are discussed . The genetic basis of disorders in the tooth development (agenesis , hypodontia ), tooth structural defects like amelogenesis imperfecta (AI ), dentinogenesis imperfecta (DI ), and oro-facial structural alterations (various syndromes ) are explained .

Diseases
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Diseases presenting "the spectrum of diseases due to genetic alterations ranges from developmental disturbances of teeth to the pre-cancerous and cancerous lesions" symptom

dentinogenesis imperfecta

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