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The fine tuning role of microRNA-RNA interaction in odontoblast differentiation and disease.
[dentinogenesis imperfecta]
Dentinogenesis
imperfecta
and
dentin
dysplasia
are
two
common
types
of
genetic
oral
diseases
resulted
from
the
aberrant
differentiation
of
odontoblast
.
Understanding
the
mechanisms
of
odontoblast
differentiation
is
crucial
for
finding
the
diagnosis
candidate
genes
and
treatment
targets
for
such
kinds
of
diseases
.
Previous
work
has
identified
a
battery
of
transcription
factors
and
growth
factors
regulating
odontoblast
differentiation
;
however
,
the
post-transcriptional
regulating
mechanisms
of
them
are
poorly
studied
.
MicroRNAs
(
miRNA
)
are
a
group
of
non-coding
RNAs
widely
studied
in
organ
development
,
inflammation
,
and
tumorigenesis
because
of
its
inhibitory
effects
on
the
target
mRNAs
.
Also
,
miRNAs
along
with
their
binding
targets
form
a
complex
competing
endogenous
RNA
(
ceRNA
)
network
where
miRNAs
serve
as
the
fine
tuning
balancers
between
their
targets
.
Recent
reports
demonstrated
the
essential
role
of
the
miRNA
pathway
in
dentinogenesis
and
the
regulatory
role
of
several
specific
miRNAs
in
the
in
vitro
model
of
odontoblast
differentiation
.
Herein
,
we
will
discuss
the
general
roles
of
miRNA
in
diseases
,
the
function
of
miRNAs
during
odontoblast
differentiation
,
and
finally
the
potential
pathological
mechanisms
through
which
miRNAs
cause
the
odontoblast-related
diseases
.
Diseases
Validation
Diseases presenting
"growth factors"
symptom
achondroplasia
alexander disease
aromatase deficiency
cholangiocarcinoma
dentin dysplasia
dentinogenesis imperfecta
dystrophic epidermolysis bullosa
kallmann syndrome
oligodontia
oral submucous fibrosis
primary effusion lymphoma
scrub typhus
severe combined immunodeficiency
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