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An overview of molecular and genetic alterations in selected benign odontogenic disorders.
[dentinogenesis imperfecta]
Some
dental
abnormalities
have
environmental
causes
.
Other
odontogenic
alterations
are
idiopathic
and
may
have
hereditary
etiologies
.
Investigations
of
these
conditions
are
ongoing
.
To
provide
a
discussion
of
developmental
odontogenic
abnormalities
and
benign
odontogenic
overgrowths
and
neoplasms
for
which
genetic
alterations
have
been
well
demonstrated
and
well
documented
.
Relevant
peer
-reviewed
literature
.
The
understanding
of
benign
odontogenic
lesions
at
a
molecular
level
is
rather
well
developed
for
some
lesions
and
at
the
initial
stages
for
many
others
.
Further
characterization
of
the
molecular
underpinnings
of
these
and
other
odontogenic
lesions
would
result
in
an
enhanced
comprehension
of
odontogenesis
and
the
pathogenesis
of
a
variety
of
odontogenic
aberrations
.
These
advancements
may
lead
to
better
prevention
and
treatment
paradigms
and
improved
patient
outcomes
.
Diseases
Validation
Diseases presenting
"neoplasms for which genetic alterations have been well demonstrated and well documented"
symptom
dentin dysplasia
dentinogenesis imperfecta
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