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Dentin sialophosphoprotein: a regulatory protein for dental pulp stem cell identity and fate.
[dentinogenesis imperfecta]
The
dentin
sialophosphoprotein
(
dspp
)
transcript
is
expressed
during
tooth
development
as
a
DSPP
precursor
protein
,
which
then
undergoes
cleavage
to
form
mature
dentin
sialoprotein
(
DSP
)
and
phosphophoryn
(
PP
)
proteins
.
Previous
studies
using
DSPP
-knockout
(
KO
)
mice
have
reported
that
these
animals
have
hypomineralized
teeth
,
thin
dentin
,
and
a
large
dental
pulp
chamber
,
similar
to
those
from
patients
with
dentinogenesis
imperfecta
III
.
However
,
there
is
no
information
about
factors
that
regulate
dental
pulp
stem
cell
lineage
fate
,
a
critical
early
event
in
the
odontoblast-dentin
mineralization
scheme
.
To
reveal
the
role
of
DSPP
in
odontoblast
lineage
differentiation
during
tooth
development
,
we
systematically
examined
teeth
from
wild-
type
(
wt
)
and
DSPP
-KO
C
5
7
BL
/
6
mice
between
the
ages
of
postnatal
day
1
and
3
months
.
We
found
developmental
abnormalities
not
previously
reported
,
such
as
circular
dentin
formation
within
dental
pulp
cells
and
altered
odontoblast
differentiation
in
DSPP
-KO
mice
,
even
as
early
as
1
day
after
birth
.
Surprisingly
,
we
also
identified
chondrocyte-like
cells
in
the
dental
pulp
from
KO-mice
teeth
.
Thus
,
these
studies
that
compare
wt
and
DSPP
-KO
mice
suggest
that
the
expression
of
DSPP
precursor
protein
is
required
for
normal
odontoblast
lineage
differentiation
and
that
the
absence
of
DSPP
allows
dental
pulp
cells
to
differentiate
into
chondrocyte-like
cells
,
which
could
negatively
impact
pulpal
wound
healing
and
tissue
regeneration
.
Diseases
Validation
Diseases presenting
"thin dentin"
symptom
dentinogenesis imperfecta
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