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Transforming growth factor-beta1 negatively regulates crystallin expression in teeth.
[dentin dysplasia]
Previously
,
we
have
reported
that
targeted
overexpression
of
transforming
growth
factor
(
TGF
)
beta
1
in
the
teeth
of
the
transgenic
mice
(
dTGF-
beta
1
)
results
in
a
novel
tooth
phenotype
phenomimicking
the
most
prevalent
tooth
disorders
in
human
.
This
phenotype
was
associated
with
discoloration
and
attrition
of
teeth
due
to
defective
mineralization
.
Here
,
we
report
a
novel
expression
of
crystallin
family
members
in
developing
mouse
teeth
and
its
regulation
by
TGF-
beta
1
in
these
transgenic
mice
.
AlphaB-
and
beta
-crystallins
were
found
to
be
elevated
in
dTGF-
beta
1
mouse
teeth
,
whereas
gamma-crystallin
(
gammaB
,
gammaC
,
and
gammaF
)
,
a
marker
of
cell
differentiation
,
was
significantly
reduced
.
Because
crystallins
are
believed
to
be
stress-related
proteins
,
their
expression
in
teeth
implicates
them
in
a
similar
role
because
teeth
are
constantly
subjected
to
physical
friction
and
temperature
fluctuations
.
