OPG knockout mouse teeth display reduced alveolar bone mass and hypermineralization in enamel and dentin.

[dentin dysplasia]

Recent studies showed that local injection or upregulation of OPG gene would result in early temporal retardation of tooth development . It was assumed that this retardation might cause defective tooth mineralization and pulp formation as the long -term effects . However , since those OPG treatments were transient , any possible long -term effects of OPG addition could not be assessed previously . In the present study , a high -resolution microCT was used to evaluate the long -term effect of OPG gene deprivation on the mineralization and morphology of mouse tooth . Our results showed that the mineralization of alveolar bone in OPG (-/-) mouse tooth was decreased while those of enamel and dentin were increased , compared with the wild-type (WT ) group . The labial and lingual dentin thicknesses of OPG (-/-) group were significantly higher and with larger area in enamel and dentin than those of WT group . The size of pulp chamber was also substantially decreased in OPG (-/-) mouse incisor . Different responses in mineralization and morphogenesis to OPG gene deprivation were found between bone and tooth . These effects may be independent of the early odontogenesis , and further studies are warranted to investigate the molecular mechanism of the effect of OPG gene expression on bone formation and later tooth development .

Diseases
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Diseases presenting "and further studies are warranted to investigate the molecular mechanism of the effect of opg gene expression on bone formation and later tooth development" symptom

dentin dysplasia

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