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OPG knockout mouse teeth display reduced alveolar bone mass and hypermineralization in enamel and dentin.
[dentin dysplasia]
Recent
studies
showed
that
local
injection
or
upregulation
of
OPG
gene
would
result
in
early
temporal
retardation
of
tooth
development
.
It
was
assumed
that
this
retardation
might
cause
defective
tooth
mineralization
and
pulp
formation
as
the
long
-term
effects
.
However
,
since
those
OPG
treatments
were
transient
,
any
possible
long
-term
effects
of
OPG
addition
could
not
be
assessed
previously
.
In
the
present
study
,
a
high
-resolution
microCT
was
used
to
evaluate
the
long
-term
effect
of
OPG
gene
deprivation
on
the
mineralization
and
morphology
of
mouse
tooth
.
Our
results
showed
that
the
mineralization
of
alveolar
bone
in
OPG
(
-
/
-
)
mouse
tooth
was
decreased
while
those
of
enamel
and
dentin
were
increased
,
compared
with
the
wild-
type
(
WT
)
group
.
The
labial
and
lingual
dentin
thicknesses
of
OPG
(
-
/
-
)
group
were
significantly
higher
and
with
larger
area
in
enamel
and
dentin
than
those
of
WT
group
.
The
size
of
pulp
chamber
was
also
substantially
decreased
in
OPG
(
-
/
-
)
mouse
incisor
.
Different
responses
in
mineralization
and
morphogenesis
to
OPG
gene
deprivation
were
found
between
bone
and
tooth
.
These
effects
may
be
independent
of
the
early
odontogenesis
,
and
further
studies
are
warranted
to
investigate
the
molecular
mechanism
of
the
effect
of
OPG
gene
expression
on
bone
formation
and
later
tooth
development
.
Diseases
Validation
Diseases presenting
"possible long-term effects"
symptom
dentin dysplasia
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