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[The advances in research on phosphorylation of polyglutamine disease].
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Polyglutamine
(
polyQ
)
diseases
are
a
group
of
hereditary
neurodegenerative
disorders
caused
by
expansion
of
a
glutamine
repeat
in
responsible
gene
products
.
To
date
,
the
pathogenesis
of
polyQ
diseases
is
still
not
very
clear
,
but
many
researches
suggest
that
phosphorylation
of
mutant
proteins
plays
a
critical
role
on
the
process
of
Huntington
's
disease
,
dentatorubral-pallidoluysian
atrophy
,
spinal
bulbar
muscular
atrophy
,
spinocerebellar
ataxia
1
and
spinocerebellar
ataxia
3
/
Machado-
Joseph
disease
.