Rare Diseases Symptoms Automatic Extraction
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Host-pathogen interactions in streptococcal immune sequelae.
[acute rheumatic fever]
Otherwise
uncomplicated
infections
with
Streptococcus
pyogenes
can
cause
two
insidious
immune
sequelae
known
as
post-streptococcal
glomerulonephritis
(
PSGN
)
and
acute
rheumatic
fever
(
ARF
)
.
These
diseases
follow
with
a
latency
of
a
few
weeks
or
months
after
primary
infection
and
are
responsible
for
high
mortality
and
morbidity
.
PSGN
has
also
been
linked
to
infections
with
group
C
streptococci
of
the
species
S
.
equi
ssp
.
zooepidemicus
(
SESZ
)
.
Moreover
,
there
are
some
indications
that
infection
with
group
C
and
G
streptococci
(
GCGS
)
of
the
subspecies
Streptococcus
dysgalactiae
ssp
.
equisimilis
(
SDSE
)
leads
to
ARF
.
Despite
decades
of
research
,
the
picture
of
the
molecular
pathogenesis
of
streptococcal
immune
sequelae
resembles
a
jigsaw
puzzle
.
Herein
we
try
to
put
some
of
the
puzzle
bits
together
that
have
been
collected
till
date
.
Diseases
Validation
Diseases presenting
"primary infection"
symptom
acute rheumatic fever
congenital toxoplasmosis
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