[Clinicopathological study of retroperitoneal sarcoma].

[dedifferentiated liposarcoma]

The purpose of this study was to retrospectively analyze the characteristics of patients with retroperitoneal sarcoma and to examine pathological findings , first site of recurrence and recurrence free-survival after surgery .From June 2003 to May 2010 , we performed 10 surgeries for retroperitoneal sarcomas . We chose 9 tumors after excluding 1 tumor that had already disseminated in the abdominal cavity . We examined patient characteristics , pathological findings and the first site of recurrence (local or distant metastasis ). We also analyzed recurrence-free survival after surgery with the Kaplan-Meier method .T he patients ' median age was 60 years (31 -71 years ), and the median tumor diameter was 10 .0 cm (2 .7 -45 cm ). Pathological diagnosis revealed 7 cases of dedifferentiated liposarcoma and 2 cases of leiomyosarcoma . En-block resection with adjacent organs was achieved in 8 of 9 patients . During follow-up , 5 of 9 patients experienced tumor local recurrence . There were no cases in which distant metastases appeared before local recurrence . The median duration between surgery and local recurrence was 13 months (3 -27 months ). The median duration from surgery to death was 30 months (5 -78 months ).Although we resected adjacent organs together when we could not achieve a sufficient margin , the rate of local recurrence after surgery for retroperitoneal sarcoma was high . Given this result using treatment with surgery alone , it is necessary to prospectively establish multimodal treatments with chemotherapy and radiotherapy to reduce local tumor recurrence .