Rare Diseases Symptoms Automatic Extraction
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Echocardiographic screening for subclinical rheumatic heart disease remains a research tool pending studies of impact on prognosis.
[acute rheumatic fever]
The
application
of
portable
echocardiography
to
the
screening
of
asymptomatic
children
and
young
adults
for
rheumatic
heart
disease
(
RHD
)
in
developing
countries
indicates
that
the
disease
may
affect
62
million
to
78
million
individuals
worldwide
,
which
could
potentially
result
in
1
.
4
million
deaths
per
year
from
RHD
and
its
complications
.
The
World
Heart
Federation
has
developed
a
guideline
for
the
echocardiographic
diagnosis
of
RHD
in
asymptomatic
individuals
without
a
history
of
acute
rheumatic
fever
(
ARF
)
in
order
to
ensure
the
reliability
,
comparability
,
and
reproducibility
of
findings
of
the
echocardiographic
screening
studies
.
Early
studies
suggest
that
a
third
of
individuals
with
asymptomatic
subclinical
RHD
revert
to
normal
echocardiographic
findings
on
repeat
testing
after
6
-
12
months
,
suggesting
that
repeat
echocardiography
may
be
necessary
to
confirm
the
findings
prior
to
consideration
of
interventions
such
as
antibiotic
prophylaxis
.
It
is
not
known
,
however
,
whether
echocardiographic
screening
for
asymptomatic
subclinical
RHD
or
the
introduction
of
antibiotic
prophylaxis
for
affected
individuals
improves
the
prognosis
of
RHD
.
Furthermore
,
the
cost-effectiveness
of
this
screening
method
has
not
been
established
in
the
vast
majority
of
affected
countries
.
Therefore
,
echocardiographic
screening
for
asymptomatic
subclinical
RHD
remains
a
research
tool
until
studies
of
impact
on
prognosis
and
cost-effectiveness
are
conducted
.
Diseases
Validation
Diseases presenting
"heart disease"
symptom
22q11.2 deletion syndrome
achondroplasia
acute rheumatic fever
adrenal incidentaloma
child syndrome
classical phenylketonuria
cohen syndrome
congenital diaphragmatic hernia
dentinogenesis imperfecta
esophageal adenocarcinoma
fabry disease
familial mediterranean fever
heparin-induced thrombocytopenia
hirschsprung disease
holt-oram syndrome
homocystinuria without methylmalonic aciduria
kabuki syndrome
monosomy 21
omenn syndrome
phenylketonuria
sneddon syndrome
systemic capillary leak syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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