Rare Diseases Symptoms Automatic Extraction
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Potential coverage of a multivalent M protein-based group A streptococcal vaccine.
[acute rheumatic fever]
The
greatest
burden
of
group
A
streptococcal
(
GAS
)
disease
worldwide
is
due
to
acute
rheumatic
fever
(
ARF
)
and
rheumatic
heart
disease
(
RHD
)
.
Safe
,
effective
and
affordable
vaccines
designed
to
prevent
GAS
infections
that
trigger
ARF
could
reduce
the
overall
global
morbidity
and
mortality
from
RHD
.
The
current
study
evaluated
the
potential
coverage
of
a
new
30
-
valent
M
protein-based
vaccine
using
GAS
isolates
from
school
children
in
Bamako
,
Mali
,
a
population
at
high
risk
for
the
development
of
RHD
.
T
he
bactericidal
activity
of
rabbit
antisera
against
the
30
-
valent
vaccine
was
assessed
using
a
collection
of
GAS
isolates
recovered
during
a
study
of
the
epidemiology
of
pharyngitis
in
Bamako
.
Single
isolates
representing
42
of
67
emm-types
,
accounting
for
85
%
of
the
GAS
infections
during
the
study
,
were
evaluated
.
All
(
14
/
14
)
of
the
vaccine
emm-types
in
the
collection
were
opsonized
(
bactericidal
killing
>
50
%
)
and
26
/
28
non-vaccine
types
were
opsonized
.
Bactericidal
activity
was
observed
against
60
%
of
the
total
emm-types
recovered
in
Bamako
,
which
accounted
for
81
%
of
all
infections
.
Multivalent
vaccines
comprised
of
N-
terminal
M
peptides
elicit
bactericidal
antibodies
against
a
broad
range
of
GAS
serotypes
,
indicating
that
their
efficacy
may
extend
beyond
the
emm-types
included
in
the
vaccine
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated