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Dedifferentiated liposarcoma of the deep (paralaryngeal) soft tissue: lessons learnt from a case with a partly deceptively benign appearing dedifferentiated component.
[dedifferentiated liposarcoma]
We
present
a
case
(
female
,
61
years
of
age
)
of
dedifferentiated
liposarcoma
of
the
deep
,
cervical
(
paralaryngeal
)
soft
tissue
with
a
significant
myxoid
component
and
characteristic
immunohistochemical
(
strong
and
diffuse
expression
of
p
16
,
mdm
2
and
cdk
4
in
both
the
well
differentiated
liposarcomatous
and
dedifferentiated
components
)
and
molecular
genetic
findings
(
MDM
2
-
gene
amplification
on
fluorescence
in
situ
hybridization
)
.
The
myxoid
component
which
was
present
in
the
well
differentiated
liposarcomatous
component
gave
the
tumor
atypical
radiological
features
.
The
case
presented
initial
diagnostic
difficulties
,
mainly
because
of
the
bland
histomorphological
appearance
of
the
limited
biopsy
material
from
the
sampled
non-lipogenic
,
dedifferentiated
component
.
The
dedifferentiated
part
of
the
tumor
turned
out
to
harbor
significant
heterogeneity
with
regards
to
cellularity
,
cytomorphology
and
proliferative
activity
.
Diseases
Validation
Diseases presenting
"characteristic immunohistochemical"
symptom
dedifferentiated liposarcoma
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