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A giant mesentery malignant solitary fibrous tumor recurring as dedifferentiated liposarcoma- a report of a very rare case and literature review.
[dedifferentiated liposarcoma]
We
report
a
case
of
a
59
-
year
-old
woman
with
a
very
rare
giant
mesentery
malignant
solitary
fibrous
tumor
that
recurred
as
dedifferentiated
liposarcoma
.
The
woman
was
admitted
to
the
hospital
because
of
low
abdominal
pain
.
Radiological
and
biopsy
findings
revealed
a
multi-lobulated
giant
malignant
solitary
fibrous
tumor
that
had
invaded
the
inferior
vena
cava
,
abdominal
aorta
,
and
superior
mesentery
vessels
.
The
tumor
was
completely
removed
during
the
first
cytoreductive
surgery
.
Histopathologically
,
tumor
had
a
heterogeneous
cell
population
,
composed
of
spindle
cells
with
fibrous
collagen
proliferation
.
The
spindle
cells
were
not
arranged
in
a
specific
pattern
.
Immunohistochemistry
revealed
that
the
tumor
cells
were
positive
for
CD
34
,
CD
99
,
Bcl-
2
,
and
smooth
muscle
actin
(
SMA
)
and
negative
for
CD
117
,
epithelial
membrane
antigen
(
EMA
)
,
CAM
5
.
7
,
S
100
,
desmin
,
and
caldesmon
.
The
tumor
recurred
9
months
after
surgery
,
and
another
cytoreductive
surgery
was
then
performed
.
The
postoperative
histopathological
appearance
of
the
invaded
area
indicated
a
well-differentiated
liposarcoma
.
Formation
of
tumorous
bone
was
also
noted
in
the
same
area
,
in
addition
to
atypical
mesenchymal
cells
and
multi-vacuolated
lipoblasts
in
the
area
of
the
well-differentiated
liposarcoma
.
Proliferated
spindle
cells
arranged
in
a
storiform
pattern
were
found
in
the
area
adjacent
to
the
tumor
.
Immunohistochemical
analysis
revealed
that
the
tumors
cells
were
positive
for
SMA
,
HHF-
35
,
and
caldesmon
and
negative
for
CD
117
,
CD
34
,
and
S
100
.
A
diagnosis
of
dedifferentiated
liposarcoma
was
made
.
Diseases
Validation
Diseases presenting
"tumor cells"
symptom
alpha-thalassemia
carcinoma of the gallbladder
cholangiocarcinoma
cushing syndrome
dedifferentiated liposarcoma
dentin dysplasia
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
pleomorphic liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
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