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DDIT3 Expression in Liposarcoma Development.
[dedifferentiated liposarcoma]
Liposarcomas
are
mesenchymal
tumors
containing
variable
numbers
of
lipoblasts
or
adipocytes
.
The
most
common
entities
,
well
differentiated
/
dedifferentiated
liposarcoma
(
WDLS
/
DDLS
)
and
myxoid
/
round
cell
liposarcoma
(
MLS
/
RCLS
)
,
are
both
characterized
by
genetic
rearrangements
that
affect
the
expression
of
the
transcription
factor
DDIT
3
.
DDIT
3
induces
liposarcoma
morphology
when
ectopically
expressed
in
a
human
fibrosarcoma
.
The
role
of
DDIT
3
in
lipomatous
tumors
is
,
however
,
unclear
.
We
have
analyzed
the
expression
of
DDIT
3
in
37
cases
of
liposarcoma
(
WDLS
/
DDLS
n
=
10
,
MLS
/
RCLS
n
=
16
,
and
pleomorphic
liposarcomas
(
PLS
)
n
=
11
)
and
11
cases
of
common
benign
lipomas
.
Major
cell
subpopulations
of
WDLS
/
DDLS
and
MLS
/
RCLS
tumors
were
found
to
express
DDIT
3
or
the
derived
fusion
protein
,
whereas
PLS
cases
showed
only
a
few
positive
cells
.
The
lipomas
contained
large
subpopulations
expressing
DDIT
3
.
No
correlation
between
numbers
of
DDIT
3
expressing
cells
and
numbers
of
lipoblasts
/
adipocytes
was
found
.
In
vitro
adipogenic
treatment
of
two
DDIT
3
expressing
cell
lines
induced
lipid
accumulation
in
small
subpopulations
only
.
Our
results
suggest
a
dual
,
promoting
and
limiting
,
role
for
DDIT
3
in
the
formation
of
lipoblasts
and
liposarcoma
morphology
.
