Computed tomography manifestations of histologic subtypes of retroperitoneal liposarcoma.

[dedifferentiated liposarcoma]

Liposarcoma (LPS ) is the most common soft tissue sarcoma and accounts for approximately 20 % of all mesenchymal malignancies , often occurring in deep soft tissue of retroperitoneal space . Accurate preoperative diagnosis is therefore necessary . We explored whether computed tomography (CT ) could be used to differentiate between the various types of retroperitoneal liposarcoma (RPLS ).Forty -seven cases of RPLS , diagnosed surgically and histologically , were analyzed retrospectively . CT features were correlated with postoperative pathological appearance .The study radiologist identified 29 , 11 , 2 , 2 and 3 RPLS as atypical lipomatous tumor /well-differentiated liposarcoma (ALT /WDL ), dedifferentiated liposarcoma (DDL ), myxoid /round cell liposarcoma (ML /RCL ), pleomorphic liposarcoma (PL ) and mixed -type liposarcoma . Analysis of CT scans revealed the following typical findings of the different subtypes of RPLS : ALT /WDL was mainly visible as a well-delineated fatty hypodense tumor with uniform density and integrity margin ; DDL was marked by the combination of focal nodular density and hypervascularity . ML /RCL , PL and mixed liposarcoma showed malignant biological behaviour and CT findings need further studies .CT scanning can reveal important details including internal components , margins and surrounding tissues . Based on CT findings , tumor type can be roughly evaluated and biopsy location and therapeutic scheme guided .

Diseases
Validation

Diseases presenting "liposarcoma" symptom

dedifferentiated liposarcoma

erdheim-chester disease

focal myositis

gm1 gangliosidosis

liposarcoma

pleomorphic liposarcoma

well-differentiated liposarcoma

This symptom has already been validated