Gankyrin is a predictive and oncogenic factor in well-differentiated and dedifferentiated liposarcoma.

[dedifferentiated liposarcoma]

Liposarcoma is one of the most common histologic types of soft tissue sarcoma and is frequently an aggressive cancer with poor outcome . Hence , alternative approaches other than surgical excision are necessary to improve treatment of well-differentiated /dedifferentiated liposarcoma (WDLPS /DDLPS ). For this reason , we performed a two -dimensional gel electrophoresis (2 -DE ) and matrix-assisted laser desorption /ionization-time of flight mass spectrometry /mass spectrometry (MALDI-TOF /MS ) analysis to identify new factors for WDLPS and DDLPS . Among the selected candidate proteins , gankyrin , known to be an oncoprotein , showed a significantly high level of expression pattern and inversely low expression of p 53 /p 21 in WDLPS and DDLPS tissues , suggesting possible utility as a new predictive factor . Moreover , inhibition of gankyrin not only led to reduction of in vitro cell growth ability including cell proliferation , colony-formation , and migration , but also in vivo DDLPS cell tumorigenesis , perhaps via downregulation of the p 53 tumor suppressor gene and its p 21 target and also reduction of AKT /mTOR signal activation . This study identifies gankyrin , for the first time , as new potential predictive and oncogenic factor of WDLPS and DDLPS , suggesting the potential for service as a future LPS therapeutic approach .

Diseases
Validation

Diseases presenting "soft tissue sarcoma" symptom

alpha-thalassemia

dedifferentiated liposarcoma

focal myositis

liposarcoma

pleomorphic liposarcoma

well-differentiated liposarcoma

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