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Gankyrin is a predictive and oncogenic factor in well-differentiated and dedifferentiated liposarcoma.
[dedifferentiated liposarcoma]
Liposarcoma
is
one
of
the
most
common
histologic
types
of
soft
tissue
sarcoma
and
is
frequently
an
aggressive
cancer
with
poor
outcome
.
Hence
,
alternative
approaches
other
than
surgical
excision
are
necessary
to
improve
treatment
of
well-differentiated
/
dedifferentiated
liposarcoma
(
WDLPS
/
DDLPS
)
.
For
this
reason
,
we
performed
a
two
-dimensional
gel
electrophoresis
(
2
-
DE
)
and
matrix-assisted
laser
desorption
/
ionization-time
of
flight
mass
spectrometry
/
mass
spectrometry
(
MALDI-TOF
/
MS
)
analysis
to
identify
new
factors
for
WDLPS
and
DDLPS
.
Among
the
selected
candidate
proteins
,
gankyrin
,
known
to
be
an
oncoprotein
,
showed
a
significantly
high
level
of
expression
pattern
and
inversely
low
expression
of
p
53
/
p
21
in
WDLPS
and
DDLPS
tissues
,
suggesting
possible
utility
as
a
new
predictive
factor
.
Moreover
,
inhibition
of
gankyrin
not
only
led
to
reduction
of
in
vitro
cell
growth
ability
including
cell
proliferation
,
colony-formation
,
and
migration
,
but
also
in
vivo
DDLPS
cell
tumorigenesis
,
perhaps
via
downregulation
of
the
p
53
tumor
suppressor
gene
and
its
p
21
target
and
also
reduction
of
AKT
/
mTOR
signal
activation
.
This
study
identifies
gankyrin
,
for
the
first
time
,
as
new
potential
predictive
and
oncogenic
factor
of
WDLPS
and
DDLPS
,
suggesting
the
potential
for
service
as
a
future
LPS
therapeutic
approach
.
Diseases
Validation
Diseases presenting
"its p21 target and also reduction of akt"
symptom
dedifferentiated liposarcoma
liposarcoma
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