Increased ischaemia-modified albumin is associated with inflammation in acute rheumatic fever.

[acute rheumatic fever]

Ischaemia-modified albumin , a novel biochemical marker for tissue ischaemia , was found to be associated with oxidative stress . The purpose of this study was to assess the role of ischaemia-modified albumin in the diagnosis of acute rheumatic fever and also to evaluate the ischaemia-modified albumin levels in children with heart valve disease .The study groups , aged 5 -18 years , consisted of 128 individuals - 40 with acute rheumatic fever , 35 with congenital heart valve disease , 33 with chronic rheumatic heart disease , and 20 healthy control subjects .The ischaemia-modified albumin , erythrocyte sedimentation rate , and C-reactive protein levels of the acute rheumatic fever group were significantly higher than those in the chronic rheumatic heart disease , congenital heart valve disease , and control groups , separately (p < 0 .001 ). The ischaemia-modified albumin levels in both carditis and isolated arthritis subgroups of children with acute rheumatic fever were significantly higher than in the control group (p < 0 .001 , p < 0 .01 , respectively ). However , there was no statistically significant difference between the chorea subgroup and control subjects . In addition , significant correlations were observed between ischaemia-modified albumin and acute phase reactants of patients with acute rheumatic fever (p < 0 .001 for both erythrocyte sedimentation rate and C-reactive protein ). The ischaemia-modified albumin levels of chronic rheumatic heart disease , congenital heart valve disease , and control subjects were similar .The increased level of ischaemia-modified albumin in children with acute rheumatic fever seems to be associated with inflammation . However , further studies are needed to provide stronger evidence .

Diseases
Validation

Diseases presenting "statistically significant difference between the chorea subgroup" symptom

acute rheumatic fever

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