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Increased ischaemia-modified albumin is associated with inflammation in acute rheumatic fever.
[acute rheumatic fever]
Ischaemia-modified
albumin
,
a
novel
biochemical
marker
for
tissue
ischaemia
,
was
found
to
be
associated
with
oxidative
stress
.
The
purpose
of
this
study
was
to
assess
the
role
of
ischaemia-modified
albumin
in
the
diagnosis
of
acute
rheumatic
fever
and
also
to
evaluate
the
ischaemia-modified
albumin
levels
in
children
with
heart
valve
disease
.
The
study
groups
,
aged
5
-
18
years
,
consisted
of
128
individuals
-
40
with
acute
rheumatic
fever
,
35
with
congenital
heart
valve
disease
,
33
with
chronic
rheumatic
heart
disease
,
and
20
healthy
control
subjects
.
The
ischaemia-modified
albumin
,
erythrocyte
sedimentation
rate
,
and
C-
reactive
protein
levels
of
the
acute
rheumatic
fever
group
were
significantly
higher
than
those
in
the
chronic
rheumatic
heart
disease
,
congenital
heart
valve
disease
,
and
control
groups
,
separately
(
p
<
0
.
001
)
.
The
ischaemia-modified
albumin
levels
in
both
carditis
and
isolated
arthritis
subgroups
of
children
with
acute
rheumatic
fever
were
significantly
higher
than
in
the
control
group
(
p
<
0
.
001
,
p
<
0
.
01
,
respectively
)
.
However
,
there
was
no
statistically
significant
difference
between
the
chorea
subgroup
and
control
subjects
.
In
addition
,
significant
correlations
were
observed
between
ischaemia-modified
albumin
and
acute
phase
reactants
of
patients
with
acute
rheumatic
fever
(
p
<
0
.
001
for
both
erythrocyte
sedimentation
rate
and
C-
reactive
protein
)
.
The
ischaemia-modified
albumin
levels
of
chronic
rheumatic
heart
disease
,
congenital
heart
valve
disease
,
and
control
subjects
were
similar
.
The
increased
level
of
ischaemia-modified
albumin
in
children
with
acute
rheumatic
fever
seems
to
be
associated
with
inflammation
.
However
,
further
studies
are
needed
to
provide
stronger
evidence
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated