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An immunohistochemical study of vitamin D receptor expression in canine cutaneous mast cell tumours.
[cutaneous mastocytosis]
The
active
form
of
vitamin
D
(
1
alpha
,
25
-
dihydroxycholecalciferol
;
calcitriol
)
has
potent
anti-neoplastic
activity
in
the
management
of
a
number
of
human
malignancies
.
Despite
promising
data
to
suggest
that
calcitriol
is
an
effective
adjunct
to
current
chemotherapy
modalities
,
the
role
of
calcitriol
in
animal
neoplasia
is
poorly
understood
.
Vitamin
D
inhibits
growth
of
canine
mast
cell
tumours
(
MCTs
)
in
vitro
,
presumably
due
to
ligand-mediated
activation
of
the
vitamin
D
receptor
(
VDR
)
.
The
aim
of
the
present
study
was
to
examine
immunohistochemically
the
expression
of
the
VDR
by
reactive
and
neoplastic
canine
cutaneous
mast
cells
.
Expression
was
graded
according
to
frequency
,
intensity
and
score
(
frequency
x
intensity
)
.
VDR
expression
was
found
in
all
samples
containing
reactive
mast
cells
(
n
=
9
)
,
and
in
67
of
69
(
97
%
)
MCTs
selected
from
each
of
the
three
Patnaik
grades
.
The
frequency
and
score
of
VDR
labelling
was
greater
in
MCTs
compared
with
reactive
mast
cells
(
P
=
0
.
0005
and
0
.
001
,
respectively
)
.
There
was
no
difference
in
VDR
frequency
between
the
MCT
grades
,
but
the
frequency
of
labelling
in
grade
3
MCTs
was
higher
than
for
reactive
mast
cells
(
P
=
0
.
001
)
.
There
was
no
association
between
tumour
mitotic
index
and
any
of
the
three
VDR
variables
(
all
P
>
0
.
16
)
.
VDR
is
widely
expressed
by
reactive
and
neoplastic
canine
mast
cells
in
vivo
.
VDR
expression
is
unlikely
to
represent
an
independent
prognostic
factor
,
but
its
presence
within
biopsy
specimens
might
be
used
to
identify
patients
that
are
suited
to
high
-dose
vitamin
D
therapeutic
trials
.
Diseases
Validation
Diseases presenting
"neoplasia"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
aniridia
carcinoma of the gallbladder
cholangiocarcinoma
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dentin dysplasia
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
hodgkin lymphoma, classical
liposarcoma
lymphangioleiomyomatosis
neuralgic amyotrophy
oligodontia
oral submucous fibrosis
pleomorphic liposarcoma
primary effusion lymphoma
pyomyositis
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wolf-hirschhorn syndrome
This symptom has already been validated
