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An immunohistochemical study of vitamin D receptor expression in canine cutaneous mast cell tumours.
[cutaneous mastocytosis]
The
active
form
of
vitamin
D
(
1
alpha
,
25
-
dihydroxycholecalciferol
;
calcitriol
)
has
potent
anti-neoplastic
activity
in
the
management
of
a
number
of
human
malignancies
.
Despite
promising
data
to
suggest
that
calcitriol
is
an
effective
adjunct
to
current
chemotherapy
modalities
,
the
role
of
calcitriol
in
animal
neoplasia
is
poorly
understood
.
Vitamin
D
inhibits
growth
of
canine
mast
cell
tumours
(
MCTs
)
in
vitro
,
presumably
due
to
ligand-mediated
activation
of
the
vitamin
D
receptor
(
VDR
)
.
The
aim
of
the
present
study
was
to
examine
immunohistochemically
the
expression
of
the
VDR
by
reactive
and
neoplastic
canine
cutaneous
mast
cells
.
Expression
was
graded
according
to
frequency
,
intensity
and
score
(
frequency
x
intensity
)
.
VDR
expression
was
found
in
all
samples
containing
reactive
mast
cells
(
n
=
9
)
,
and
in
67
of
69
(
97
%
)
MCTs
selected
from
each
of
the
three
Patnaik
grades
.
The
frequency
and
score
of
VDR
labelling
was
greater
in
MCTs
compared
with
reactive
mast
cells
(
P
=
0
.
0005
and
0
.
001
,
respectively
)
.
There
was
no
difference
in
VDR
frequency
between
the
MCT
grades
,
but
the
frequency
of
labelling
in
grade
3
MCTs
was
higher
than
for
reactive
mast
cells
(
P
=
0
.
001
)
.
There
was
no
association
between
tumour
mitotic
index
and
any
of
the
three
VDR
variables
(
all
P
>
0
.
16
)
.
VDR
is
widely
expressed
by
reactive
and
neoplastic
canine
mast
cells
in
vivo
.
VDR
expression
is
unlikely
to
represent
an
independent
prognostic
factor
,
but
its
presence
within
biopsy
specimens
might
be
used
to
identify
patients
that
are
suited
to
high
-dose
vitamin
D
therapeutic
trials
.
