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Mastocytosis in pregnancy.
[cutaneous mastocytosis]
Mastocytosis
is
a
rare
disorder
characterized
by
abnormal
accumulation
of
mast
cells
in
various
organs
.
Clinical
complaints
include
pruritus
,
cutaneous
flushing
,
dyspepsia
,
and
episodes
of
anaphylaxis
,
and
are
usually
the
result
of
local
and
systemic
mast
cell
mediator
release
.
The
triggers
include
a
variety
of
factors
including
drugs
,
exercise
,
stress
,
anxiety
,
and
temperature
extremes
.
A
26
-
year
-old
primigravida
at
40
weeks
'
gestation
with
urticaria
pigmentosa
presented
to
our
hospital
.
She
was
diagnosed
with
cutaneous
mastocytosis
based
on
pathologic
examination
of
her
skin
biopsy
.
There
were
no
complications
during
pregnancy
,
except
for
cutaneous
manifestations
with
pruritus
and
premature
uterine
contractions
at
27
weeks
'
gestation
.
After
admission
,
antihistamine
agents
were
administered
during
labor
to
treat
the
above
symptoms
,
and
antibiotic
agents
were
given
for
prophylaxis
of
chorioamnionitis
.
Labor
pain
was
successfully
managed
with
warm
showers
,
frequent
position
changes
and
massage
,
and
therefore
,
epidural
analgesia
was
not
carried
out
.
After
6
hours
of
labor
,
the
patient
gave
birth
to
a
healthy
female
infant
via
normal
spontaneous
vaginal
delivery
with
right
mediolateral
episiotomy
.
Neither
local
anesthetic
agents
nor
antibiotic
agents
caused
any
reaction
.
The
postpartum
period
was
uneventful
.
Pregnant
women
with
mastocytosis
should
be
treated
symptomatically
and
should
avoid
factors
that
may
exacerbate
symptoms
of
disease
.
Clinicians
should
be
aware
of
preterm
labor
during
pregnancy
.
As
a
preventive
measure
,
resuscitation
equipment
should
be
available
during
the
labor
,
delivery
and
postpartum
period
to
treat
unanticipated
hypotension
and
shock
.
Diseases
Validation
Diseases presenting
"pruritus"
symptom
benign recurrent intrahepatic cholestasis
cholangiocarcinoma
cutaneous mastocytosis
dystrophic epidermolysis bullosa
erdheim-chester disease
lamellar ichthyosis
pleomorphic liposarcoma
pyomyositis
zellweger syndrome
This symptom has already been validated