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The effects of topical sodium cromoglicate on itch and flare in human skin induced by intradermal histamine: a randomised double-blind vehicle controlled intra-subject design trial.
[cutaneous mastocytosis]
Itch
is
a
prominent
feature
of
many
skin
diseases
,
particularly
atopic
dermatitis
and
cutaneous
mastocytosis
.
Sodium
cromoglicate
(
SCG
)
,
a
chromone
developed
for
the
treatment
of
allergic
disease
has
been
shown
to
reduce
the
severity
of
itch
when
applied
topically
to
subjects
with
atopic
dermatitis
.
The
aim
of
this
study
was
to
investigate
whether
topical
sodium
cromoglicate
can
reduce
the
severity
of
itch
induced
by
intradermal
histamine
.
SCG
was
introduced
into
the
skin
of
healthy
volunteers
both
by
iontophoresis
and
by
topical
application
using
a
new
4
%
cutaneous
emulsion
(
Altoderm
™
)
.
The
skin
was
then
challenged
with
intradermal
histamine
.
Measurements
were
made
of
severity
of
itch
,
size
of
wheal
and
flare
and
change
in
blood
fluxSCG
significantly
reduced
the
severity
of
itch
(
P
=
0
.
0045
)
and
flare
(
P
=
0
.
0143
)
when
delivered
by
iontophoresis
.
SCG
4
%
cutaneous
emulsion
significantly
reduced
severity
of
itch
(
P
=
0
.
024
)
and
flare
(
P
=
0
.
015
)
in
atopic
subjects
.
Trend
analysis
showed
increasing
effect
on
itch
with
increased
concentrations
of
SCG
,
which
was
significant
(
P
=
0
.
046
)
.
There
were
no
effects
on
wheal
or
blood
flux
.
Topically
applied
SCG
,
administered
in
a
new
cutaneous
emulsion
base
,
significantly
reduced
the
itch
and
flare
caused
by
intradermal
histamine
.
The
effect
was
greatest
in
atopic
subjects
and
increased
with
the
concentration
of
SCG
in
the
emulsion
.
ISRCTN
35671014
.
