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The value of immunohistochemical expression of BAX in formulating a prognosis for canine cutaneous mast cell tumours.
[cutaneous mastocytosis]
Immunohistochemical
expression
of
BAX
was
evaluated
in
24
canine
cutaneous
mast
cell
tumours
in
order
to
verify
the
relationship
of
this
expression
to
the
histopathological
grade
of
the
lesions
and
its
prognostic
value
for
clinical
outcome
.
BAX
expression
increased
with
higher
histopathological
grades
(
P
=
0
.
0148
;
P
<
0
.
05
between
grades
I
and
III
)
.
Animals
with
high
levels
of
BAX
expression
were
4
.
25
times
more
likely
to
die
from
the
disease
and
had
shorter
post-surgical
survival
times
(
P
=
0
.
0009
)
.
These
results
suggest
that
alterations
in
BAX
expression
may
be
related
to
the
aggressiveness
of
canine
cutaneous
mast
cell
tumours
,
indicating
that
immunohistochemical
detection
of
BAX
may
be
predictive
of
clinical
outcome
.
Diseases
Validation
Diseases presenting
"canine cutaneous mast cell tumours"
symptom
cutaneous mastocytosis
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