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Serotonin and its 5-HT1 receptor in human mastocytosis.
[cutaneous mastocytosis]
Human
mastocytosis
is
a
rare
disease
,
in
which
the
serotonergic
system
may
be
involved
.
The
objective
of
the
present
study
was
to
examine
the
possible
presence
of
serotonin
(
5
-
HT
)
and
its
5
-
HT
1
A
receptor
(
R
)
in
the
skin
of
patients
with
mastocytosis
.
In
addition
,
the
effect
of
the
5
-
HT
1
AR
was
tested
on
human
mastocytosis
cells
,
cultured
in
vitro
.
The
expression
of
5
-
HT
and
5
-
HT
1
AR
in
patients
with
urticaria
pigmentosa
and
mastocytoma
was
studied
using
immunohistochemistry
.
The
effects
of
8
-
OH
-DPAT
,
an
agonist
of
5
-
HT
1
AR
,
on
the
proliferation
(
cell
number
)
,
viability
,
apoptosis
,
spontaneous
release
of
histamine
,
as
well
as
a
possible
5
-
HT
metabolism
,
in
the
human
HMC-
1
mast
cell
line
,
were
investigated
.
Both
5
-
HT
and
5
-
HT
1
AR
were
expressed
in
the
mast
cells
in
biopsies
of
mastocytoma
and
urticaria
pigmentosa
,
as
well
as
in
HMC-
1
cells
.
However
,
no
metabolism
of
5
-
HT
by
the
cell
line
could
be
detected
by
the
methodology
used
.
The
5
-
HT
1
AR
agonist
had
no
significant
effect
on
the
viability
and
number
of
HMC-
1
cells
,
and
was
without
effect
on
the
apoptosis
.
At
concentrations
of
10
â»
â¶
mol
/
L
and
10
â»
â¸
-
10
â»
¹â°
mol
/
L
(
i
.
e
.
also
at
physiological
concentrations
)
,
the
agonist
inhibited
histamine
release
by
these
cells
by
as
much
as
30
%
.
These
findings
indicate
that
5
-
HT
and
its
5
-
HT
1
AR
are
expressed
in
human
mastocytosis
and
that
an
agonist
of
the
5
-
HT
1
AR
might
be
of
value
in
the
treatment
of
these
patients
.
Diseases
Validation
Diseases presenting
"spontaneous release"
symptom
cutaneous mastocytosis
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