Rare Diseases Symptoms Automatic Extraction
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Evaluation of serum ischemia modified albumin levels in acute rheumatic fever before and after therapy.
[acute rheumatic fever]
To
investigate
ischemia
modified
albumin
(
IMA
)
levels
in
children
with
acute
rheumatic
fever
(
ARF
)
before
and
after
therapy
and
compare
them
with
those
of
controls
.
Twenty
seven
patients
with
ARF
and
18
healthy
,
age
and
sex
matched
children
were
included
in
the
study
.
The
diagnosis
of
ARF
was
established
according
to
the
modified
Jones
criteria
.
Follow-up
studies
were
made
when
acute
phase
reactants
[
erythrocyte
sedimentation
rate
(
ESR
)
,
C-
reactive
protein
(
CRP
)
]
levels
returned
normal
.
IMA
levels
were
measured
using
the
rapid
and
colorimetric
method
with
the
albumin
cobalt
binding
test
.
IMA
levels
were
significantly
higher
in
ARF
group
(
p
 
<
 
0
.
001
)
compared
with
controls
at
the
time
on
admission
.
IMA
(
absorbance
units
)
was
measured
as
0
.
41
 
±
 
0
.
10
in
the
control
group
,
0
.
55
(
0
.
44
-
1
.
13
)
in
the
study
group
before
treatment
and
0
.
48
 
±
 
0
.
12
in
the
study
group
after
treatment
.
After
treatment
,
statistically
important
decrements
were
determined
in
the
levels
of
ESR
(
p
<
0
.
001
)
,
CRP
(
p
<
0
.
001
)
and
IMA
(
p
<
0
.
01
)
.
There
was
no
significant
difference
for
IMA
levels
between
after
treatment
and
control
group
.
IMA
levels
at
the
time
on
admission
correlated
positively
with
ESR
(
r
 
=
 
0
.
605
,
p
 
<
 
0
.
01
)
and
CRP
(
r
 
=
 
0
.
543
,
p
 
<
 
0
.
01
)
.
The
present
study
shows
that
increased
serum
IMA
levels
in
patients
with
ARF
at
the
time
of
diagnosis
is
a
sign
of
increased
inflammation
.
Thus
,
serum
IMA
levels
may
be
used
as
a
follow-up
marker
like
CRP
and
ESR
for
evaluating
the
efficacy
of
treatment
in
ARF
.
