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Serum tenascin-C: a novel biomarker for diagnosis and predicting prognosis of rheumatic carditis?
[acute rheumatic fever]
Tenascin-
C
(
TnC
)
is
an
extracellular
matrix
glycoprotein
that
has
a
major
role
in
tissue
remodeling
.
To
evaluate
the
serum
TnC
level
in
acute
rheumatic
fever
(
ARF
)
and
chronic
rheumatic
heart
disease
(
CRHD
)
during
childhood
.
Twenty
-
five
patients
with
ARF
,
25
patients
with
CRHD
and
20
control
subjects
were
included
in
the
study
.
The
TnC
levels
were
analyzed
using
the
enzyme-linked
immunosorbent
assay
method
in
the
ARF
group
.
T
he
TnC
levels
were
lower
in
the
acute
carditis
group
compared
with
the
control
group
(
p
<
0
.
001
)
.
The
cut-off
level
was
estimated
as
2
.
08
ng
/
ml
for
diagnosing
carditis
with
93
.
3
%
sensitivity
and
95
%
specificity
.
On
second
analysis
,
prominent
decrease
was
detected
in
valve
insufficiency
patients
with
markedly
elevated
TnC
levels
.
In
the
CRHD
group
,
TnC
level
was
significantly
lower
in
cases
with
severe
valve
insufficiency
(
p
<
0
.
001
)
.
Serum
TnC
level
can
be
used
as
a
new
biochemical
marker
for
diagnosis
and
predicting
the
prognosis
of
rheumatic
carditis
.
Diseases
Validation
Diseases presenting
"heart disease"
symptom
22q11.2 deletion syndrome
achondroplasia
acute rheumatic fever
adrenal incidentaloma
child syndrome
classical phenylketonuria
cohen syndrome
congenital diaphragmatic hernia
dentinogenesis imperfecta
esophageal adenocarcinoma
fabry disease
familial mediterranean fever
heparin-induced thrombocytopenia
hirschsprung disease
holt-oram syndrome
homocystinuria without methylmalonic aciduria
kabuki syndrome
monosomy 21
omenn syndrome
phenylketonuria
sneddon syndrome
systemic capillary leak syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
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