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Evaluation of a modified proportional margins approach for surgical resection of mast cell tumors in dogs: 40 cases (2008-2012).
[cutaneous mastocytosis]
To
evaluate
a
modified
proportional
margins
approach
to
resection
of
mast
cell
tumors
(
MCTs
)
in
dogs
.
Retrospective
case
series
.
40
dogs
with
subcutaneous
and
cutaneous
MCTs
undergoing
curative
intent
surgery
.
Medical
records
were
searched
to
identify
dogs
with
a
cytologically
or
histologically
confirmed
diagnosis
of
MCT
that
had
not
previously
been
treated
surgically
and
that
had
undergone
full
oncological
staging
.
In
those
dogs
,
tumors
were
resected
with
lateral
margins
equivalent
to
the
widest
measured
diameter
of
the
tumor
and
a
minimum
depth
of
1
well-defined
fascial
plane
deep
to
the
tumor
.
Surgical
margins
were
evaluated
histologically
.
Cutaneous
tumors
were
graded
by
use
of
the
Patnaik
system
and
the
2
-
tier
system
described
by
Kiupel
et
al
.
The
prognosis
for
subcutaneous
tumors
was
assessed
in
accordance
with
published
recommendations
.
Follow-up
information
on
dog
health
status
was
obtained
through
clinical
examination
,
the
dog
owners
,
and
the
referring
veterinarians
.
The
40
dogs
had
47
tumors
.
Forty
-
one
(
87
%
)
tumors
were
cutaneous
,
and
6
(
13
%
)
were
subcutaneous
.
On
the
basis
of
the
Patnaik
system
,
21
(
51
%
)
cutaneous
tumors
were
considered
grade
I
,
18
(
44
%
)
were
considered
grade
II
,
and
2
(
5
%
)
were
considered
grade
III
.
On
the
basis
of
the
Kiupel
system
,
37
(
90
%
)
cutaneous
tumors
were
considered
low
grade
,
and
4
(
10
%
)
were
considered
high
grade
.
The
prognosis
for
the
6
subcutaneous
tumors
was
classified
as
likely
resulting
in
a
shorter
(
2
)
or
longer
(
4
)
survival
time
.
Forty
tumors
were
deemed
to
have
been
excised
with
clear
margins
and
7
with
incomplete
margins
.
Local
recurrence
was
not
recorded
for
any
dog
but
was
suspected
for
1
(
2
%
)
tumor
,
although
not
confirmed
.
Interval
from
tumor
excision
to
follow-up
ranged
from
30
to
1
,
140
days
(
median
,
420
days
)
.
The
modified
proportional
margins
system
resulted
in
satisfactory
local
disease
control
in
dogs
with
MCTs
.
Diseases
Validation
Diseases presenting
"subcutaneous tumors"
symptom
cutaneous mastocytosis
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