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Omalizumab as a desensitizing agent and treatment in mastocytosis: a review of the literature and case report.
[cutaneous mastocytosis]
Patients
with
all
forms
of
mastocytosis
can
experience
urticaria
,
abdominal
cramps
,
nausea
,
diarrhea
,
or
hypotension
due
to
release
of
mediators
by
mast
cells
.
Patients
with
mastocytosis
and
Hymenoptera
venom
allergy
can
develop
severe
adverse
reactions
to
Hymenoptera
stings
.
In
addition
,
patients
with
mastocytosis
and
on
venom
immunotherapy
are
at
high
risk
for
incomplete
protection
and
fatal
reactions
.
Recent
literature
has
reported
the
use
of
omalizumab
as
an
adjunctive
treatment
in
patients
with
mastocytosis
,
used
for
both
symptom
improvement
and
to
dampen
adverse
effects
caused
by
venom
immunotherapy
.
This
article
reviews
the
literature
regarding
omalizumab
use
in
the
treatment
of
mastocytosis
and
for
protection
against
the
adverse
effects
during
venom
immunotherapy
.
In
addition
,
we
report
the
case
of
a
patient
at
high
risk
and
with
cutaneous
mastocytosis
,
whose
symptoms
improved
with
concomitant
administration
of
omalizumab
and
venom
immunotherapy
.
Diseases
Validation
Diseases presenting
"high risk"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
aniridia
canavan disease
congenital diaphragmatic hernia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
harlequin ichthyosis
heparin-induced thrombocytopenia
hirschsprung disease
hodgkin lymphoma, classical
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
krabbe disease
legionellosis
liposarcoma
locked-in syndrome
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
phenylketonuria
primary hyperoxaluria type 1
severe combined immunodeficiency
sneddon syndrome
waldenström macroglobulinemia
werner syndrome
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