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Omalizumab as a desensitizing agent and treatment in mastocytosis: a review of the literature and case report.
[cutaneous mastocytosis]
Patients
with
all
forms
of
mastocytosis
can
experience
urticaria
,
abdominal
cramps
,
nausea
,
diarrhea
,
or
hypotension
due
to
release
of
mediators
by
mast
cells
.
Patients
with
mastocytosis
and
Hymenoptera
venom
allergy
can
develop
severe
adverse
reactions
to
Hymenoptera
stings
.
In
addition
,
patients
with
mastocytosis
and
on
venom
immunotherapy
are
at
high
risk
for
incomplete
protection
and
fatal
reactions
.
Recent
literature
has
reported
the
use
of
omalizumab
as
an
adjunctive
treatment
in
patients
with
mastocytosis
,
used
for
both
symptom
improvement
and
to
dampen
adverse
effects
caused
by
venom
immunotherapy
.
This
article
reviews
the
literature
regarding
omalizumab
use
in
the
treatment
of
mastocytosis
and
for
protection
against
the
adverse
effects
during
venom
immunotherapy
.
In
addition
,
we
report
the
case
of
a
patient
at
high
risk
and
with
cutaneous
mastocytosis
,
whose
symptoms
improved
with
concomitant
administration
of
omalizumab
and
venom
immunotherapy
.
Diseases
Validation
Diseases presenting
"diarrhea"
symptom
acute rheumatic fever
adrenomyeloneuropathy
benign recurrent intrahepatic cholestasis
cutaneous mastocytosis
esophageal carcinoma
fabry disease
familial mediterranean fever
hirschsprung disease
kabuki syndrome
legionellosis
lymphangioleiomyomatosis
omenn syndrome
pendred syndrome
phenylketonuria
primary effusion lymphoma
primary hyperoxaluria type 1
scrub typhus
systemic capillary leak syndrome
triple a syndrome
typhoid
von hippel-lindau disease
waldenström macroglobulinemia
wiskott-aldrich syndrome
This symptom has already been validated