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Cutaneous mastocytosis combined with eruptive melanocytic nevi and melanoma. Coincidence or a linkage in the pathogenesis?
[cutaneous mastocytosis]
Cellular
combinations
in
the
same
neoplasm
can
have
intriguing
physiopathological
implications
,
which
may
be
useful
to
better
understand
the
biology
of
the
diseases
.
Urticaria
pigmentosa
in
association
with
eruptive
melanocytic
nevi
was
observed
in
a
female
patient
.
Maculopapular
lesions
extended
at
the
base
of
different
melanocytic
nevi
and
the
histopathological
examination
revealed
the
presence
of
a
mast
cell
population
in
the
papillary
and
reticular
dermis
combined
with
overlying
melanocytic
nevi
.
The
re
-evaluation
of
a
melanoma
removed
three
years
before
revealed
the
presence
of
the
same
pathological
features
.
Immunohistochemical
assays
showed
a
strong
positivity
to
Giemsa
,
Toluidine
blue
and
CD-
117
in
the
mast
cells
,
while
a
S-
100
reaction
was
observed
in
the
melanocytic
population
.
We
discuss
possible
pathogenetic
linkage
between
cutaneous
mastocytosis
and
melanoma
.
