Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
The expression of melanoma inhibitory activity on mast cells in child patients with cutaneous mastocytosis.
[cutaneous mastocytosis]
Cutaneous
mastocytosis
is
a
disorder
characterized
by
the
proliferation
of
mast
cells
in
the
skin
.
Melanoma
inhibitory
activity
(
MIA
)
is
a
serum
marker
for
malignant
melanoma
.
However
,
it
has
not
been
known
on
MIA
expression
of
cutaneous
mastocytosis
.
We
investigated
the
expression
of
MIA
in
4
child
patients
with
cutaneous
mastocytosis
immunohistochemically
and
serum
MIA
level
in
1
patient
by
enzyme-linked
immunosorbent
assay
.
Histopathological
examination
revealed
diffuse
mast
cell
infiltration
in
the
dermis
.
MIA
was
positive
for
infiltrating
mast
cells
in
all
patients
.
Serum
level
of
MIA
was
elevated
in
1
patient
.
Although
it
was
difficult
to
assess
the
significance
of
elevated
serum
levels
of
MIA
in
child
patients
,
MIA
was
expressed
on
infiltrating
mast
cells
in
our
study
.
Based
on
our
findings
,
mast
cell-derived
MIA
might
be
related
to
the
formation
of
pigmented
regions
in
cutaneous
mastocytosis
.
