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[Clinical factors affecting quality of life and treatment targets in patients with myasthenia gravis].
[cushing syndrome]
Presently
,
myasthenia
gravis
(
MG
)
is
seldom
lethal
.
However
,
full
remission
without
immune
treatment
is
not
common
,
and
many
patients
still
find
it
difficult
to
maintain
daily
activities
.
To
both
determine
factors
affecting
health-related
quality
of
life
(
QOL
)
and
propose
an
appropriate
treatment
target
for
patients
with
MG
,
we
evaluated
640
consecutive
patients
with
MG
seen
at
11
neurological
centers
.
Two
-
year
follow-up
data
were
obtained
for
282
patients
.
Correlations
between
detailed
clinical
facotrs
and
the
Japanese
version
of
the
15
-
item
MG-
specific
QOL
scale
were
analyzed
.
In
the
cross-sectional
analysis
of
640
MG
patients
,
multivariate
regression
revealed
that
disease
severity
as
evaluated
by
MG
Composite
(
p
<
0
.
0001
)
,
but
not
quantitative
MG
score
,
total
dose
of
oral
prednisolone
(
p
=
0
.
002
)
,
but
not
current
dose
,
and
Cushingoid
appearance
index
(
p
=
0
.
0004
)
showed
significant
negative
effects
on
QOL
.
Achieving
status
of
Minimal
Manifestations
or
better
with
prednisolone
≤
5
mg
/
day
was
found
to
exert
a
major
positive
impact
on
QOL
in
both
the
cross-sectional
and
2
-
year
follow-up
patient
samples
and
can
be
recommended
as
a
treatment
target
.
Diseases
Validation
Diseases presenting
"major positive impact"
symptom
cushing syndrome
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