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Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism.
[cushing syndrome]
Glucocorticoids
(
GCs
)
are
critical
in
the
regulation
of
the
stress
response
,
inflammation
and
energy
homeostasis
.
Excessive
GC
exposure
results
in
whole-body
insulin
resistance
,
obesity
,
cardiovascular
disease
,
and
ultimately
decreased
survival
,
despite
their
potent
anti-
inflammatory
effects
.
This
apparent
paradox
may
be
explained
by
the
complex
actions
of
GCs
on
adipose
tissue
functionality
.
The
wide
prevalence
of
oral
GC
therapy
makes
their
adverse
systemic
effects
an
important
yet
incompletely
understood
clinical
problem
.
This
article
reviews
the
mechanisms
by
which
supraphysiologic
GC
exposure
promotes
insulin
resistance
,
focusing
in
particular
on
the
effects
on
adipose
tissue
function
and
lipid
metabolism
.
Diseases
Validation
Diseases presenting
"adverse systemic effects"
symptom
cushing syndrome
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