Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Juvenile generalized pustular psoriasis treated with etanercept.
[cushing syndrome]
An
8
-
year
-old
boy
with
general
pustular
psoriasis
(
GPP
)
and
iatrogenic
secondary
Cushing
syndrome
was
treated
successfully
with
etanercept
after
he
had
failed
on
acitretin
,
methotrexate
,
and
methylprednisolone
therapy
.
GPP
is
a
severe
and
very
rare
variant
of
psoriasis
in
children
often
accompanied
by
life-threatening
complications
.
Retinoids
,
cyclosporine
,
methotrexate
,
or
dapsone
used
in
a
small
number
of
case
series
and
case
reports
were
effective
.
Etanercept
is
a
recombinant
human
tumor
necrosis
factor
-alpha
(
TNF
-alpha
)
receptor
protein
fused
with
Fc
portion
of
IgG
1
that
binds
to
TNF
-alpha
,
approved
by
Food
and
Drug
Administration
for
the
treatment
of
moderate
-
to
-
severe
plaque
psoriasis
in
children
and
teens
who
have
not
responded
to
other
psoriasis
treatments
.
In
our
patient
,
etanercept
demonstrated
significant
clinical
response
associated
with
long
-term
efficacy
without
acute
exacerbation
,
excellent
tolerability
,
and
good
safety
profile
.
Diseases
Validation
Diseases presenting
"psoriasis"
symptom
cushing syndrome
epidermolysis bullosa simplex
harlequin ichthyosis
hodgkin lymphoma, classical
lamellar ichthyosis
omenn syndrome
severe combined immunodeficiency
systemic capillary leak syndrome
werner syndrome
This symptom has already been validated