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Juvenile generalized pustular psoriasis treated with etanercept.
[cushing syndrome]
An
8
-
year
-old
boy
with
general
pustular
psoriasis
(
GPP
)
and
iatrogenic
secondary
Cushing
syndrome
was
treated
successfully
with
etanercept
after
he
had
failed
on
acitretin
,
methotrexate
,
and
methylprednisolone
therapy
.
GPP
is
a
severe
and
very
rare
variant
of
psoriasis
in
children
often
accompanied
by
life-threatening
complications
.
Retinoids
,
cyclosporine
,
methotrexate
,
or
dapsone
used
in
a
small
number
of
case
series
and
case
reports
were
effective
.
Etanercept
is
a
recombinant
human
tumor
necrosis
factor
-alpha
(
TNF
-alpha
)
receptor
protein
fused
with
Fc
portion
of
IgG
1
that
binds
to
TNF
-alpha
,
approved
by
Food
and
Drug
Administration
for
the
treatment
of
moderate
-
to
-
severe
plaque
psoriasis
in
children
and
teens
who
have
not
responded
to
other
psoriasis
treatments
.
In
our
patient
,
etanercept
demonstrated
significant
clinical
response
associated
with
long
-term
efficacy
without
acute
exacerbation
,
excellent
tolerability
,
and
good
safety
profile
.
