Medullary thyroid carcinoma with ectopic adrenocorticotropic hormone syndrome.

[cushing syndrome]

Ectopic adrenocorticotropic hormone (ACTH ) syndrome is caused most frequently by a bronchial carcinoid tumor or by small cell lung cancer . Medullary thyroid carcinoma (MTC ) is a rare etiology of ectopic ACTH syndrome . We describe a case of Cushing syndrome due to ectopic ACTH production from MTC in a 48 -year -old male . He was diagnosed with MTC 14 years ago and underwent total thyroidectomy , cervical lymph node dissection and a series of metastasectomies . MTC was confirmed by the pathological examination of the thyroid and metastatic mediastinal lymph node tissues . Two years after his last surgery , he developed Cushingoid features , such as moon face and central obesity , accompanied by uncontrolled hypertension and new-onset diabetes . The laboratory results were compatible with ectopic ACTH syndrome . A bilateral adrenalectomy improved the clinical and laboratory findings that were associated with Cushing syndrome . This is the first confirmed case of ectopic ACTH syndrome caused by MTC in Korea .

Diseases
Validation

Diseases presenting "obesity" symptom

acute rheumatic fever

adrenal incidentaloma

aniridia

aromatase deficiency

carcinoma of the gallbladder

cohen syndrome

congenital adrenal hyperplasia

cushing syndrome

cystinuria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

heparin-induced thrombocytopenia

kabuki syndrome

monosomy 21

phenylketonuria

primary hyperoxaluria type 1

sneddon syndrome

werner syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated